![I don't understand the mechanism of the methylation with trimethyl orthoformate. Also what is the role of the NH4NO3 in the reaction? Lastly what is the role of the quaternary ammonium salt I don't understand the mechanism of the methylation with trimethyl orthoformate. Also what is the role of the NH4NO3 in the reaction? Lastly what is the role of the quaternary ammonium salt](https://preview.redd.it/oc08w0eoclq31.png?auto=webp&s=926df726c3c99b17807ad5a852b757974c243d59)
I don't understand the mechanism of the methylation with trimethyl orthoformate. Also what is the role of the NH4NO3 in the reaction? Lastly what is the role of the quaternary ammonium salt
![Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source | Journal of the American Chemical Society Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source | Journal of the American Chemical Society](https://pubs.acs.org/cms/10.1021/jacs.0c02805/asset/images/medium/ja0c02805_0005.gif)
Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source | Journal of the American Chemical Society
![A practical fluorous benzylidene acetal protecting group for a quick synthesis of disaccharides - ScienceDirect A practical fluorous benzylidene acetal protecting group for a quick synthesis of disaccharides - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S004040390700768X-fx1.jpg)
A practical fluorous benzylidene acetal protecting group for a quick synthesis of disaccharides - ScienceDirect
![Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K](https://pubs.rsc.org/image/article/2020/RA/d0ra05276k/d0ra05276k-s12.gif)
Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K
![Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K](https://pubs.rsc.org/image/article/2020/RA/d0ra05276k/d0ra05276k-s46.gif)
Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K
![Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source. - Abstract - Europe PMC Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source. - Abstract - Europe PMC](https://europepmc.org/articles/PMC7450724/bin/nihms-1616849-f0006.jpg)
Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source. - Abstract - Europe PMC
![Catalysts | Free Full-Text | Reaction of Glycerol with Trimethyl Orthoformate: Towards the Synthesis of New Glycerol Derivatives Catalysts | Free Full-Text | Reaction of Glycerol with Trimethyl Orthoformate: Towards the Synthesis of New Glycerol Derivatives](https://www.mdpi.com/catalysts/catalysts-09-00534/article_deploy/html/images/catalysts-09-00534-sch001.png)
Catalysts | Free Full-Text | Reaction of Glycerol with Trimethyl Orthoformate: Towards the Synthesis of New Glycerol Derivatives
![organic chemistry - Mechanism of enolether formation with ethyl orthoformate in estr-4-ene-3,17-dione (Djerassi's norethisterone synthesis) - Chemistry Stack Exchange organic chemistry - Mechanism of enolether formation with ethyl orthoformate in estr-4-ene-3,17-dione (Djerassi's norethisterone synthesis) - Chemistry Stack Exchange](https://i.stack.imgur.com/6fcXI.png)
organic chemistry - Mechanism of enolether formation with ethyl orthoformate in estr-4-ene-3,17-dione (Djerassi's norethisterone synthesis) - Chemistry Stack Exchange
![Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K](https://pubs.rsc.org/image/article/2020/RA/d0ra05276k/d0ra05276k-s83.gif)
Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media - RSC Advances (RSC Publishing) DOI:10.1039/D0RA05276K
![SOLVED: 1) Show the mechanism of the formation of an acetal from a carbonyl compound. (Hint: the reaction does not require the trimethyl orthoformate. A protonation starts the process.) Which parts of SOLVED: 1) Show the mechanism of the formation of an acetal from a carbonyl compound. (Hint: the reaction does not require the trimethyl orthoformate. A protonation starts the process.) Which parts of](https://cdn.numerade.com/ask_previews/2e753329-aeed-45e1-b81d-12127f428934_large.jpg)
SOLVED: 1) Show the mechanism of the formation of an acetal from a carbonyl compound. (Hint: the reaction does not require the trimethyl orthoformate. A protonation starts the process.) Which parts of
![In situ formed acetals facilitated direct Michael addition of unactivated ketones - New Journal of Chemistry (RSC Publishing) DOI:10.1039/C6NJ02954J In situ formed acetals facilitated direct Michael addition of unactivated ketones - New Journal of Chemistry (RSC Publishing) DOI:10.1039/C6NJ02954J](https://pubs.rsc.org/image/article/2017/NJ/c6nj02954j/c6nj02954j-s2_hi-res.gif)
In situ formed acetals facilitated direct Michael addition of unactivated ketones - New Journal of Chemistry (RSC Publishing) DOI:10.1039/C6NJ02954J
![Three Solvent‐Free Catalytic Approaches to the Acetal Functionalization of Carbohydrates and Their Applicability to One‐Pot Generation of Orthogonally Protected Building Blocks - Traboni - 2015 - Advanced Synthesis & Catalysis - Wiley Online Library Three Solvent‐Free Catalytic Approaches to the Acetal Functionalization of Carbohydrates and Their Applicability to One‐Pot Generation of Orthogonally Protected Building Blocks - Traboni - 2015 - Advanced Synthesis & Catalysis - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/06243879-4e57-4ec8-adef-e04668ae552a/mcontent.gif)
Three Solvent‐Free Catalytic Approaches to the Acetal Functionalization of Carbohydrates and Their Applicability to One‐Pot Generation of Orthogonally Protected Building Blocks - Traboni - 2015 - Advanced Synthesis & Catalysis - Wiley Online Library
![A Simple and Versatile Method for the Formation of Acetals/Ketals Using Trace Conventional Acids | ACS Omega A Simple and Versatile Method for the Formation of Acetals/Ketals Using Trace Conventional Acids | ACS Omega](https://pubs.acs.org/cms/10.1021/acsomega.8b00159/asset/images/large/ao-2018-00159k_0010.jpeg)
A Simple and Versatile Method for the Formation of Acetals/Ketals Using Trace Conventional Acids | ACS Omega
![SOLVED: 1. Hemiacetals and acetals are formed by reaction of ketones or aldehydes with alcohols in the presence of an acid catalyst: Hemiacetals are generated when 1 equiv. ofthe corresponding alcohol is SOLVED: 1. Hemiacetals and acetals are formed by reaction of ketones or aldehydes with alcohols in the presence of an acid catalyst: Hemiacetals are generated when 1 equiv. ofthe corresponding alcohol is](https://cdn.numerade.com/ask_images/f37827535f6b4450ab2a04c5c78b922b.jpg)
SOLVED: 1. Hemiacetals and acetals are formed by reaction of ketones or aldehydes with alcohols in the presence of an acid catalyst: Hemiacetals are generated when 1 equiv. ofthe corresponding alcohol is
![Synthesis of dimethyl acetal of ketones: design of solid acid catalysts for one-pot acetalization reaction - ScienceDirect Synthesis of dimethyl acetal of ketones: design of solid acid catalysts for one-pot acetalization reaction - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1387181104004925-gr2.jpg)